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Prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13–14 years in Northeast Iran

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《医学前沿（英文）》 2016年 第10卷 第3期   页码 345-350 doi: 10.1007/s11684-016-0462-y

摘要：

Asthma is the most common chronic disease among children, and its incidences are often imminent among elementary schoolchildren. This study aimed to examine the prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13–14 years in Northeast Iran. The prevalence rate was compared according to age group (aged 6–7 years vs. aged 13–14 years) and gender (male vs. female). In this cross-sectional study, 1706 Iranian schoolchildren aged 6–7 and 13–14 years in Golestan Province were enrolled. Participants completed questionnaires between February and July 2014. Asthma symptoms were assessed using the questionnaire of the International Study of Asthma and Allergies in Childhood protocol in Persian. The logistic regression model was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of the asthma symptoms for each of the gender and age groups. The prevalence rates of “current asthma” symptoms and “asthma ever” in all the children were estimated as 9.5% and 7.5%, respectively. The prevalence of asthma (“asthma ever” and “wheezing in the past 12 months”) in junior high schoolchildren (aged 13–14 years) is higher than that in elementary schoolchildren (aged 6–7 years) (P <0.05). The prevalence of the severity of wheezing in girls is lower than that in boys (OR= 1.7, 95%CI= 1.06–2.96, P = 0.02). Asthma is still a major public health problem. This study shows that the prevalence of the asthma symptoms in boys is lower than that in girls in both age groups, and the severity of asthma in girls is higher than that in boys aged 13–14 years.

关键词： asthma     asthma symptoms     epidemiology     childhood     chronic disease    

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Lung function and air pollution exposure in adults with asthma in Beijing: a 2-year longitudinal panel

《医学前沿（英文）》 2022年 第16卷 第4期   页码 574-583 doi: 10.1007/s11684-021-0882-1

摘要： The effect of air pollution on the lung function of adults with asthma remains unclear to date. This study followed 112 patients with asthma at 3-month intervals for 2 years. The pollutant exposure of the participants was estimated using the inverse distance weight method. The participants were divided into three groups according to their lung function level at every visit. A linear mixed-effect model was applied to predict the change in lung function with each unit change in pollution concentration. Exposure to carbon monoxide (CO) and particles less than 2.5 micrometers in diameter (PM2.5) was negatively associated with large airway function in participants. In the severe group, exposure to chronic sulfur dioxide (SO2) was negatively associated with post-bronchodilator forced expiratory flow at 50%, between 25% and 75% of vital capacity % predicted (change of 95% CI per unit: −0.34 (−0.55, −0.12), −0.24 (−0.44, −0.03), respectively). In the mild group, the effect of SO2 on the small airways was similar to that in the severe group, and it was negatively associated with large airway function. Exposure to CO and PM2.5 was negatively associated with the large airway function of adults with asthma. The negative effects of SO2 were more evident and widely observed in adults with severe and mild asthma than in adults with moderate asthma. Patients with asthma react differently to air pollutants as evidenced by their lung function levels.

关键词： lung function     asthma     air pollution     adult    

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Not asthma, but GERD: case report

WANG Zhonggao

《医学前沿（英文）》 2007年 第1卷 第1期   页码 115-119 doi: 10.1007/s11684-007-0022-6

摘要： Asthma is a disorder of the lungs characterized by increased responsiveness of the airways, as manifested by episodes of wheezing and increased resistance to expiratory airflow because of varying degrees of smooth muscle contraction, edema of the mucosa, and mucus in the lumen of the bronchi and bronchioles. The stimuli vary widely and include antigens, infection, air pollutants, respiratory tract irritants, exercise, and emotional factors. This condition is completely different from distress breathing because of laryngotracheal spasm. One of its causes is the gastric content reflux through the pharynx to the larynx because of gastroesophageal reflux disease (GERD), in addition to the typical human avian flu that may cause immediate suffocation by laryngospasm owing to acute larygotrachitis. A patient suffered from GERD without esophageal symptoms, which was diagnosed and treated as bronchial asthma during his five emergency admissions. The admissions were because of episodic attacks of severe air hunger owing to an extreme throat tightening. The patient was being treated for as long as two years. After the correct diagnosis was made and treatment of laporascopic fundaplication was performed, the longstanding bronchial asthma , after all, completely disappeared. The concept of not asthma, but GERD seems undervalued, unappreciated, even misunderstood among patients with intractable asthma. Therefore, such a case is reported in detail, similar cases are mentioned briefly as well, and a mechanism responsible for GERD-originated larryngo- or laryngotracho-spasm is proposed.

关键词： resistance     mechanism responsible     unappreciated     responsiveness     different    

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Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomized

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《医学前沿（英文）》 2018年 第12卷 第3期   页码 340-349 doi: 10.1007/s11684-017-0565-0

摘要：

Benralizumab is a monoclonal antibody that targets interleukin-5 receptor α to deplete blood eosinophils and improve the clinical outcomes of allergic asthma. We conducted a meta-analysis to evaluate the safety and efficacy of different doses of benralizumab in patients with eosinophilic asthma. All randomized controlled trials involving benralizumab treatment for patients with eosinophilic asthma, which were searched in PubMed, Embase, and the Cochrane Library published until January 2017, as well as the rate of asthmatic exacerbation, pulmonary functionality, asthma control, quality of life scores, and adverse events were included. Randomized-effect models were used in the meta-analysis to calculate the pooled mean difference, relative risks, and 95% confidence intervals. Five studies involving 1951 patients were identified. Compared with the placebo, benralizumab treatment demonstrated significant improvements in the forced expiratory volume in 1?s (FEV1), Asthma Quality of Life Questionnaire scores, decreased asthmatic exacerbation and Asthma Control Questionnaire-6 (ACQ-6) scores. Benralizumab treatment was also not associated with increased adverse events. These findings indicated that benralizumab can be safely used to improve FEV1, enhance patient symptom control and quality of life, and reduce the risk of exacerbations and ACQ-6 scores in patients with eosinophilic asthma. Furthermore, our meta-analysis showed that benralizumab with 30 mg (every eight weeks) dosage can improve the health-related quality of life and appear to be more effective than 30 mg (every four weeks) dosage. Overall, data indicated that the optimal dosing regimen for benralizumab was possibly 30 mg (every eight weeks).

关键词： benralizumab     anti-interleukin-5     monoclonal antibody     eosinophilic asthma     meta-analysis    

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Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing

《医学前沿（英文）》 2022年 第16卷 第6期   页码 919-931 doi: 10.1007/s11684-021-0918-6

摘要： Preeclampsia (PE) is characterized by placenta-mediated pregnancy complication. The only effective treatment for PE is the delivery of the placenta. However, this treatment may cause preterm birth and neonatal death. Therefore, preventing PE is needed. The mechanism of PE involves abnormal placentation, which leads to the release of anti-angiogenic and inflammatory mediators into maternal circulation. These mediators contribute to systemic vascular dysfunction, inflammatory responses, and excessive thrombin generation. Microparticles (MPs) are reportedly involved in PE by promoting the thromboinflammatory response. This study describes a strategy to prevent PE by reducing MP release using the recombinant protein, diannexin. Results showed that the patients with PE had elevated MP number and procoagulant activity and increased NLRP3 inflammasome activation. Additionally, diannexin remarkably reduced the release of MPs from activated cells by binding to phosphatidylserine exposed on the surface of activated cells. Moreover, in vivo results showed that diannexin could prevent PE-like symptoms by decreasing MPs and NLRP3 inflammasome activation in pregnant mice. Furthermore, diannexin effectively inhibited trophoblast cell activation and NLRP3 inflammasome activation in vitro. These findings suggested that diannexin inhibited MP release and might be an effective therapeutic strategy for preventing PE.

关键词： preeclampsia     recombinant protein diannexin     microparticle     NLRP3 inflammasome     phosphatidylserin    

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A belated revelation: from gastroesophageal reflux derived asthma to laryngotracheal irritation even

WANG Zhonggao

《医学前沿（英文）》 2008年 第2卷 第2期   页码 127-129 doi: 10.1007/s11684-008-0023-0

摘要： The author has been inspired by the Global Evidence-Based Consensus for gastroesophageal reflux (GER), which put forward four extra-esophageal syndromes: reflux cough syndrome, reflux laryngitis syndrome, reflux dental erosion syndrome and the reflux asthma syndrome. The author himself happened to receive five emergency rescue treatments following apparent “bronchial asthma”, which was to be diagnosed as GER at his own insistence. PPI resulted in some relief. After being rescued again from suffocation, he had a fundaplication, which was performed at the Englewood Hospital & Medical Center, Englewood, USA in March 2006. The procedure immediately cleared up his “asthma”. A month later he brought forth a Center for GER in an army hospital in Beijing, China. Up to now, 601 patients with mainly respiratory distress (84%) were treated by Stretta Radiofrequency, 58 by surgery and more by PPI. The GER Center is now complete with a ward. GER patients with respiratory distresses turned out to fare better than those with acid regurgitation. A nozzle-shaped pharynx was found in patients with the reflux. Animal study revealed that the refluxate entered into trachea and even lungs. Gradually a hypothesis of a gastro-oesophago-laryngo-tracheal reflux took shape.Our modest effort to treat GER-derived respiratory distresses has got off to an encouraging start amid relative shortage of experience and facilities. We would like to share two thoughts with scholars and experts at home and abroad:1. The GER-derived asthma is not asthma, but GER pure and simple;2. The pathogenesis of “asthma” is not asthma, but laryngotracheal irritation/spasm and its sequence.

关键词： laryngotracheal irritation/spasm     gastro-oesophago-laryngo-tracheal     sequence     fundaplication     encouraging    

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Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study

Siyi Li, Peilin Lv, Min He, Wenjing Zhang, Jieke Liu, Yao Gong, Ting Wang, Qiyong Gong, Yulin Ji, Su Lui

《医学前沿（英文）》 2020年 第14卷 第6期   页码 792-801 doi: 10.1007/s11684-020-0745-1

摘要： Asthma is a serious health problem that involves not only the respiratory system but also the central nervous system. Previous studies identified either regional or network alterations in patients with asthma, but inconsistent results were obtained. A key question remains unclear: are the regional and neural network deficits related or are they two independent characteristics in asthma? Answering this question is the aim of this study. By collecting resting-state functional magnetic resonance imaging from 39 patients with asthma and 40 matched health controls, brain functional measures including regional activity (amplitude of low-frequency fluctuations) and neural network function (degree centrality (DC) and functional connectivity) were calculated to systematically characterize the functional alterations. Patients exhibited regional abnormities in the left angular gyrus, right precuneus, and inferior temporal gyrus within the default mode network. Network abnormalities involved both the sensorimotor network and visual network with key regions including the superior frontal gyrus and occipital lobes. Altered DC in the lingual gyrus was correlated with the degree of airway obstruction. This study elucidated different patterns of regional and network changes, thereby suggesting that the two parameters reflect different brain characteristics of asthma. These findings provide evidence for further understanding the potential cerebral alterations in the pathophysiology of asthma.

关键词： asthma     brain     regional activation     functional connectivity     resting-state fMRI    

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Outcome of Stretta radiofrequency and fundoplication for GERD-related severe asthmatic symptoms

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《医学前沿（英文）》 2015年 第9卷 第4期   页码 437-443 doi: 10.1007/s11684-015-0422-y

摘要：

This study aimed to investigate the outcome of treatment with Stretta radiofrequency (SRF) or laparoscopic Nissen fundoplication (LNF). A total of 137 gastroesophageal reflux disease (GERD) patients with severe asthmatic symptoms who responded inadequately to medical treatment for asthma were investigated. The patients were followed up 1 year and 5 years after SRF (n = 82) or LNF (n = 55) treatment. A questionnaire covering 29 related symptoms and medication use was employed. Digestive, respiratory, and ear-nose-throat (ENT) symptom scores significantly decreased after antireflux treatment. Symptom scores respectively changed from 17.2±10.1, 31.9±6.6, and 21.1±11.8 to 5.0±6.2, 11.5±10.2, and 6.3±6.8 at 1 year and to 5.6±6.5, 13.1±10.1, and 7.8±7.2 at 5 years (P <0.001). The outcome of LNF was significantly better than that of SRF in terms of digestive (P <0.001, P = 0.001), respiratory (P = 0.006, P = 0.001), and ENT symptoms (P = 0.006, P = 0.003) at both 1 year and 5 years. SRF and LNF were both effective against the digestive symptoms of GERD as well as GERD-related severe asthmatic and ENT symptoms, with better outcomes exhibited by the LNF group. Severe asthmatic symptoms and GERD were closely associated, and this finding warrants further study.

关键词： asthma     gastroesophageal reflux     Stretta radiofrequency     laparoscopic Nissen fundoplication    

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肝硬化患者胃黏膜微生物菌群特征及其与胃肠道症状的相关性分析 Article

陈燕飞, 郭静, 陈春雷, 石鼎, 方戴琼, 季峰, 李兰娟

《工程（英文）》 2021年 第7卷 第4期   页码 507-514 doi: 10.1016/j.eng.2020.04.014

摘要：

研究表明，肝硬化患者的口腔和肠道微生物群与健康人群存在差异。胃位于口腔和肠道之间，关于其黏膜微生物群结构所知甚少。本研究采用16S rRNA焦磷酸测序技术分析了肝硬化患者和对照组的胃黏膜微生物群。研究发现，组织学和测序法均证实肝硬化患者幽门螺杆菌感染率显著降低。在幽门螺杆菌阴性人群中，可以按细菌组成结构将胃黏膜微生物群分为4个聚类，其中聚类1和2主要是肝硬化患者，聚类3主要是健康人群，而聚类4中肝硬化患者和健康人群各占一半左右。这些不同聚类间的成分和功能存在显著差异。在属的水平上，聚类1和2分别富集奈瑟菌和链球菌。在功能基因分类上，相对而言，聚类2缺乏涉及遗传信息处理以及与聚糖生物合成和代谢相关的功能基因。胃黏膜菌群结构表现为聚类2的患者胃肠道症状更严重，既往内镜下曲张静脉的治疗率显著高于其他组。我们的研究结果表明，在肝硬化中，幽门螺杆菌和非幽门螺杆菌的定植都受到影响。虽然幽门螺杆菌阴性的胃黏膜微生物结构表现出相当大的异质性，但特定的胃微生物群与临床特征之间仍然存在相关性。既往内镜下静脉曲张治疗会引起胃黏膜菌群结构明显改变，从而加重幽门螺杆菌阴性肝硬化患者的胃肠道症状。

关键词： 微生物组     肝硬化     症状     静脉曲张     胃镜    

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A giant Müllerian duct cyst in the perineum: a case report

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《医学前沿（英文）》 2012年 第6卷 第4期   页码 440-443 doi: 10.1007/s11684-012-0222-6

摘要：

The authors present a case report of a giant Müllerian duct cyst in the perineum. A 37-year-old man presented with a mass with the size of 50 cm×40 cm×30 cm in the perineum. Computed tomography (CT) scan and magnetic resonance imaging (MRI) of the pelvis and perineum found a huge multilocular cystic mass. X-ray film of the pelvis showed a giant soft-tissue shadow of high density in the perineum. Voiding cystourethrogram did not show any cyst interlinked to posterior urethra. After related examinations, the patient underwent open surgical resection of the cyst. Pathologic examination confirmed the presence of a Müllerian duct cyst. Huge Müllerian duct cyst is uncommon in clinic. Treatments of Müllerian duct cysts depend on their sizes and symptoms.

关键词： Müllerian duct cyst     clinical symptoms     diagnosis    

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Characterization of hidden rules linking symptoms and selection of acupoint using an artificial neural

Won-Mo Jung, In-Soo Park, Ye-Seul Lee, Chang-Eop Kim, Hyangsook Lee, Dae-Hyun Hahm, Hi-Joon Park, Bo-Hyoung Jang, Younbyoung Chae

《医学前沿（英文）》 2019年 第13卷 第1期   页码 112-120 doi: 10.1007/s11684-017-0582-z

摘要： Comprehension of the medical diagnoses of doctors and treatment of diseases is important to understand the underlying principle in selecting appropriate acupoints. The pattern recognition process that pertains to symptoms and diseases and informs acupuncture treatment in a clinical setting was explored. A total of 232 clinical records were collected using a Charting Language program. The relationship between symptom information and selected acupoints was trained using an artificial neural network (ANN). A total of 11 hidden nodes with the highest average precision score were selected through a tenfold cross-validation. Our ANN model could predict the selected acupoints based on symptom and disease information with an average precision score of 0.865 (precision, 0.911; recall, 0.811). This model is a useful tool for diagnostic classification or pattern recognition and for the prediction and modeling of acupuncture treatment based on clinical data obtained in a real-world setting. The relationship between symptoms and selected acupoints could be systematically characterized through knowledge discovery processes, such as pattern identification.

关键词： acupuncture     indication     neural network     pattern identification     prediction    

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Tim-3 mRNA expression in peripheral blood lymphocytes from asthmatic patients

Xiaoxia LU, Weikun HU, Shengdao XIONG, Guopeng XU, Fen LAN

《医学前沿（英文）》 2009年 第3卷 第2期   页码 187-190 doi: 10.1007/s11684-009-0033-6

摘要： The study aimed to detect the expression of the Th1-specific cell surface protein T cell Ig and mucin domain-containing molecule-3 (Tim-3) mRNA in peripheral blood lymphocytes isolated from asthmatic patients and to examine the correlation among Tim-3 mRNA, interleukin-4 (IL-4), interferon-γ (IFN-γ) level, and FEV1/FVC (force expiratory volume in one second/forced vital capacity) to explore the role of Tim-3 in the development and progression of asthmatic inflammation. Tim-3 mRNA expression was detected by reverse transcription polymerase chain reaction (RT-PCR). The IL-4 and IFN-γ levels were determined by using enzyme-linked immunosorbent assay (ELISA). The correlation among Tim-3 mRNA, IL-4, IFN-γ level, and pulmonary ventilatory capacity was analyzed. The expression of Tim-3 mRNA in patients with acute asthma exacerbation was 0.39±0.06, significantly higher than that in patients at the remission stage and controls (0.18±0.05 and 0.07±0.03, <0.05). The level of IL-4 in patients with acute asthma exacerbation was 68.42±10.54, significantly higher than that in the patients at the remission stage and controls (41.83±9.37 and 32.75±8.16, <0.05). The level of IL-4 in patients in remission was significantly higher than that in controls ( <0.05). The level of IFN-γ in patients with acute asthma exacerbation was 65.74±7.85, significantly lower than that in patients in remission and the control group (120.84±11.62 and 139.65±13.47, <0.05). The level of IFN-γ in patients in asthma remission was significantly lower than that in controls ( <0.05). Tim-3 mRNA expression was positively correlated with the level of IL-4 ( =0.68, <0.05) and negatively with the level of IFN-γ and pulmonary ventilatory capacity ( =-0.85, =-0.76, both <0.01). The increased expression of Tim-3 mRNA in peripheral blood lymphocytes might be involved in the development and progression of asthmatic inflammation.

关键词： asthma     airway inflammation     peripheral blood lymphocyte     Tim-3    

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Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle

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《医学前沿（英文）》 2015年 第9卷 第1期   页码 117-122 doi: 10.1007/s11684-014-0343-1

摘要：

At the very time of global paying the highest attention to the worst insults of smoking as well as haze on the airway, everybody knows both are exogenous and noticeable. However, people mostly, including many medical personnel, do not know how badly the gastroesophageal reflux (GER) insults on our own airway. Symptoms of GER are commonly seen as heartburn and regurgitation, which can be mostly tolerated. However, when the up going gastric content reversely passes the esophagus and then the distal pharynx, where it appears a beak like stricture, serving as a nozzle, so as to produce numerous micro-particles and reach the oro-nasal cavity and also the airway causing allergic rhinitis and asthmatic attacks, even pulmonary parenchyma lesions. It will reduce life quality or even jeopardize life. The point that the endogenous insult appears in the respiratory system, but originates from the digestive tract is not well known and often undiagnosed and not correctly treated. The GER induced airway challenge is a treatable and preventive entity, as soon as a diagnosis is made, a good relief could be expected by means of life style adjustment, medicine, or fixation of the patulous cardia through radiofrequency or fundoplication. The author Dr. Zhonggao Wang had suffered it for long and symptoms disappeared for 8 years after anti-reflux surgery. Here is a presentation of Dr. Zhonggao Wang and his team’s work and would call attention to the public so as to recognize this relatively unknown entity — a treatable condition occurring from human itself, but not from outside surroundings as smoking or haze does.

关键词： gastroesophageal reflux     airway     pharyngeal nozzle     micro-aspiration     asthma    

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Symptom network topological features predict the effectiveness of herbal treatment for pediatric cough

Mengxue Huang, Jingjing Wang, Runshun Zhang, Zhuying Ni, Xiaoying Liu, Wenwen Liu, Weilian Kong, Yao Chen, Tiantian Huang, Guihua Li, Dan Wei, Jianzhong Liu, Xuezhong Zhou

《医学前沿（英文）》 2020年 第14卷 第3期   页码 357-367 doi: 10.1007/s11684-019-0699-3

摘要： Pediatric cough is a heterogeneous condition in terms of symptoms and the underlying disease mechanisms. Symptom phenotypes hold complicated interactions between each other to form an intricate network structure. This study aims to investigate whether the network structure of pediatric cough symptoms is associated with the prognosis and outcome of patients. A total of 384 cases were derived from the electronic medical records of a highly experienced traditional Chinese medicine (TCM) physician. The data were divided into two groups according to the therapeutic effect, namely, an invalid group (group A with 40 cases of poor efficacy) and a valid group (group B with 344 cases of good efficacy). Several well-established analysis methods, namely, statistical test, correlation analysis, and complex network analysis, were used to analyze the data. This study reports that symptom networks of patients with pediatric cough are related to the effectiveness of treatment: a dense network of symptoms is associated with great difficulty in treatment. Interventions with the most different symptoms in the symptom network may have improved therapeutic effects.

关键词： pediatric cough     complex network     symptoms     traditional Chinese medicine     electronic medical records    

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起病时无呼吸道症状或发热的重型或危重型COVID-19患者的临床特征及转归 Article

许娟娟, 殷峥嵘, 刘宇, 汪速飞, 段丽敏, 安義, 范金烁, 廖婷婷, 金阳, 陈建国

《工程（英文）》 2021年 第7卷 第10期   页码 1454-1460 doi: 10.1016/j.eng.2020.09.009

摘要：

以不典型症状起病的新型冠状病毒肺炎（COVID-19）患者在早期容易漏诊，部分患者可发展为重症甚至危重症，目前尚缺乏相关的临床研究。本研究回顾了在起病时无典型症状（呼吸道症状或发热）的重型或危重型COVID-19患者的临床、实验室和影像学特征及治疗情况，并随访至患者死亡或治愈出院。2020年1月25日至2020年2月10日期间，武汉协和医院西院共收治943例COVID-19患者，其中909例（96.4%）重型或危重型COVID-19患者中有10例（1.1%）患者在起病时无呼吸系统症状或发热。10例患者的中位年龄为63岁[四分位区间（IQR）：57~72]，其中7例为男性。从出现症状到入院的中位时间为14 d（IQR：7~20）。10例患者中有8例患有慢性基础疾病。入院时，5例患者有乏力症状（n = 5）、4例有头痛或头晕（n = 4）、5例有腹泻（n = 5）、3例有厌食（n = 3）、3例有恶心或呕吐（n = 3）以及1例患者有眼部不适症状（n = 1）。4例患者外周血淋巴细胞减少。影像学检查显示9例患者有双侧肺炎，1例有单侧肺炎。最终2例患者死亡，8例患者治愈出院。8例患者从入院到出院的中位时间为24 d（IQR：13~43）。总的来说，部分重型或危重型COVID-19 患者在起病时无呼吸道症状或发热，此类不典型患者应尽早发现和隔离，否则可能延误病情，导致住院时间延长，甚至死亡。因此，对COVID-19患者密切接触者，即使无呼吸道症状或发热，也应及时进行核酸检测或胸部CT扫描以筛查不典型症状患者。

关键词： 新型冠状病毒（SARS-CoV-2）     新型冠状病毒肺炎（COVID-19）     不典型的     临床特征    

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标题 作者 时间 类型 操作

Prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13–14 years in Northeast Iran

null

期刊论文

Lung function and air pollution exposure in adults with asthma in Beijing: a 2-year longitudinal panel

期刊论文

Not asthma, but GERD: case report

WANG Zhonggao

期刊论文

Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomized

null

期刊论文

Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing

期刊论文

A belated revelation: from gastroesophageal reflux derived asthma to laryngotracheal irritation even

WANG Zhonggao

期刊论文

Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study

Siyi Li, Peilin Lv, Min He, Wenjing Zhang, Jieke Liu, Yao Gong, Ting Wang, Qiyong Gong, Yulin Ji, Su Lui

期刊论文

Outcome of Stretta radiofrequency and fundoplication for GERD-related severe asthmatic symptoms

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肝硬化患者胃黏膜微生物菌群特征及其与胃肠道症状的相关性分析

陈燕飞, 郭静, 陈春雷, 石鼎, 方戴琼, 季峰, 李兰娟

期刊论文

A giant Müllerian duct cyst in the perineum: a case report

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Characterization of hidden rules linking symptoms and selection of acupoint using an artificial neural

Won-Mo Jung, In-Soo Park, Ye-Seul Lee, Chang-Eop Kim, Hyangsook Lee, Dae-Hyun Hahm, Hi-Joon Park, Bo-Hyoung Jang, Younbyoung Chae

期刊论文

Tim-3 mRNA expression in peripheral blood lymphocytes from asthmatic patients

Xiaoxia LU, Weikun HU, Shengdao XIONG, Guopeng XU, Fen LAN

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Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle

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Symptom network topological features predict the effectiveness of herbal treatment for pediatric cough

Mengxue Huang, Jingjing Wang, Runshun Zhang, Zhuying Ni, Xiaoying Liu, Wenwen Liu, Weilian Kong, Yao Chen, Tiantian Huang, Guihua Li, Dan Wei, Jianzhong Liu, Xuezhong Zhou

期刊论文

起病时无呼吸道症状或发热的重型或危重型COVID-19患者的临床特征及转归

许娟娟, 殷峥嵘, 刘宇, 汪速飞, 段丽敏, 安義, 范金烁, 廖婷婷, 金阳, 陈建国

期刊论文